Solubility of 2-isopropylimidazole in nine pure organic solvents and liquid mixture of (methanol + ethyl acetate) from T = (278.15 to 313.15) K: Experimental measurement and thermodynamic modelling

Abstract

Solubility of 2-isopropylimidazole in nine organic solvents including methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, ethyl acetate, toluene, 2-butanone and liquid mixture of (methanol+ethyl acetate) were determined experimentally by using the isothermal saturation method over the temperature range from (278.15 to 313.15)K under atmosphere pressure (101.2kPa). The solubility of 2-isopropylimidazole in the pure solvents increased with a rise of temperature. In general, the mole fraction solubility obeyed the following order from high to low in different pure solvents: methanol>ethanol>2-butanone>n-propanol>acetone>isopropanol>ethyl acetate>acetonitrile>toluene. For the (methanol+ethyl acetate) mixture with given initial composition, the mole fraction solubility of 2-isopropylimidazole increase with increasing temperature and mass fraction of methanol. The obtained solubility of 2-isopropylimidazole in the pure solvents was correlated with the modified Apelblat equation and λh equation; and in the binary solvent mixture, the Jouyban–Acree model, van’t Hoff–Jouyban–Acree model and modified Apelblat–Jouyban–Acree model. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) were 19.29×10−3 and 1.07%, respectively. In addition, the standard dissolution enthalpy was calculated.