Abstract
The solubility of 4-guanidinobenzoic acid hydrochloride (4-GABCL) in pure solvents (H2O, methanol, ethanol, n-propanol, isopropanol, 1-butanol, and 1-pentanol) and two binary solvents (H2O + ethanol/isopropanol) were determined by the dynamic saturation method in the temperature range of 294.55 K–333.65 K under atmospheric pressure. From the measurement results, it could be observed that the solubility of 4-GABCL in both pure and binary solvents all increased with increasing temperature. The solubility order of 4-GABCL in pure solvents was ranked as follows: methanol > H2O > n-propanol > ethanol > n-butanol > isopropanol > n-pentanol. The solubility of 4-GABCL in binary solvents tended to increase and then decrease with increasing molar fractions of ethanol and isopropanol, and the solubility of the solute in the binary solvents was greater than that of each in the monosolvents. In addition, Ideal model, Apelblat model, λh model, Wilson model, and NRTL model had been used to correlate the solubility of 4-GABCL in pure and binary solvents. Correlated effects show that the Wilson model gives the best correlation. The influence of solvents on the solubility of 4-GABCL was further studied by KAT-LSER model. The results showed that the solubility was mainly affected by the polarizability and the self-viscosity of the solvent.The mixing and dissolution thermodynamic properties of 4-GABCL in all experimental solvents had been calculated and analyzed by using the Wilson equation and solvent data. It was determined that the mixing and dissolution of 4-GABCL were spontaneous, endothermic and entropy-driven in the study systems. Besides, the solubility order of the pure solvent is consistent with the dissolution entropy at a temperature of 318.15 k.
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