Abstract
The present study illustrates the formation and characterization of three different cocrystals of ezetimibe using methyl paraben as a coformer, employing three different processes, namely, solution crystallization, liquid assisted grinding, and reaction crystallization. Thermal analysis by differential scanning calorimetry (DSC) and thermogravimetric analysis were used as a primary analytical tool, followed by spectroscopic and crystallographic study as a confirmatory analytical tool. Equilibrium aqueous solubility studies were performed for all cocrystals taking ezetimibe as the control. The ideal solubility of drug and cocrystals was also calculated using data obtained from DSC (heat of fusion, ΔH, and transition melting temperature, Tm). The equilibrium aqueous solubility of ezetimibe was enhanced by about 2-fold in the case of cocrystal prepared by solution crystallization. Cocrystals prepared via reaction crystallization showed solubility that was almost the same as that of pure ezetimibe. The dissol...
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