Abstract
The solubility of mebendazole and flubendazole was measured in aqueous buffers (pH 2.0 and pH 7.4), hexane, and octanol in the temperature range of 293.15–313.15 K by the shake flask method. The molecule ionization state effect on the solubility was investigated. The ionization constants of the compounds at different temperatures were derived from the solubility data. The distribution coefficients in the octanol/buffer (pH 2.0) system at (293.15–313.15 K) and in the hexane/buffer (pH 2.0) system at 298.15 K were measured. The hydrogen bonding potential of the compounds was evaluated using the ΔlogD parameter. The thermodynamic functions of the dissolution and transfer process between the organic and aqueous phases were calculated and discussed. The permeability coefficients through the PermeaPad barrier were determined. The dependences between the distribution and permeability parameters and structural descriptor ΣCad/α were analyzed to obtain the correlation equations.
Published Version
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