Solubility and Dissolution Enhancement of Rosuvastatin Calcium by Using HPMC & Guar Gum Polymers and Formulated into Capsule Dosage Form

Abstract

The main objective of the current study was to prepare the solid dispersions of Rosuvastatin calcium and formulated into capsule dosage form with the combination of different polymers. Solid dispersions are prepared by fusion method by using combination of polymers in different concentrations such as HPMC and Guar gum. Solid dispersion technique will be selected as an efficient means for improving the solubility, dissolution rate and improves the bioavailability of water insoluble drugs. Solid dispersion of Rosuvastatin by the above mentioned method increases the dissolution rate of Rosuvastatin. These solid dispersions will be evaluated by parameters such as drug content, solubility, X-RD, percentage yield, DSC and in-vitro dissolution profile. The stability study of the formulations as per ICH guideline Q1A in stability chamber both at intermediate and accelerated conditions ascertained that the formulations are stable at wide range of storage conditions.