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Abstract
Spherical crystallization technique combines crystallization followed by agglomeration to generate spherical crystals with improved micromeretic properties, thus obviating need for further processing by agglomeration and granulation. The present study was focused on spherical crystallization of an antihelmentic drug Albendazole (ABZ) using spherical crystallization technique. Apart from being poorly water-soluble, ABZ exhibits poor flow and compressibility owing to its needle shaped crystal habit and electrostatic charge. Spherical agglomeration was carried out in the presence of different bridging liquids (hexane, octanol, dichloromethane) and polymers (Carboxymethyl Celluose Sodium [Na CMC] and Hydroxyl propyl methyl cellulose [HPMC]), by employing different crystallization conditions such as variation of polymer type, polymer concentration, variation of bridging liquid, bridging liquid concentration, rate of stirring and stirring time. The final parameters were optimized to obtain crystals for the formulation of tablet through direct compression. The agglomerates exhibited better flow properties, higher bulk density and improved compressibility compared to pure powder drug. Spherical crystals generated in the presence of Sodium CMC and HPMC indicated better compressibility of spherical crystals than the spherical crystals prepared with organic solvents in the absence of Sodium CMC and HPMC.
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