Solitary Fibrous Tumor of Oral Cavity: Report of Three New Cases

Abstract

Solitary fibrous tumor (SFT) is uncommon in the oral cavity, predominantly affecting the buccal mucosa and tongue of adult women. We describe here 3 additional cases of oral SFT. All patients were women with a mean age of 52 years (range 41-63 years). The tumors presented as slow-growing, asymptomatic, and well-defined submucosal nodules with a smooth surface, located in the buccal mucosa (2 cases) and posterior lower vestibule (1 case). The latter case measured 5 cm and caused superficial bone erosion of the mandible. Gross analysis revealed whitish fibrous appearance of the cut surface. Microscopic analysis revealed typical circumscribed spindle-cell proliferation, with a variably collagenized stroma and staghorn-shaped vessels, exhibiting positivity for CD34, bcl-2, and CD99. All three patients are well, and recurrence has not been observed after follow-up varying from 6 to 18 months. Clinicians should consider oral SFT when evaluating well-defined nodules in the buccal mucosa.