Abstract
This chapter reviews established and emerging analytical and physical techniques for the characterization of amorphous solid dispersions. The thermal analysis methods used in most reported studies of amorphous solid dispersions include differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and isothermal microcalorimetry (ITC). Many of the commonly used polymers in amorphous solid dispersions are hydrophilic in nature and contain polar functional groups, and can absorb moisture from the atmosphere. In the pharmaceutical sciences, vibrational spectroscopic methods are generally used to probe molecular vibrations and phonon modes in crystalline substances. Solid‐state nuclear magnetic resonance (SSNMR) analysis of mobility in amorphous solid dispersions is complementary to thermal analysis and dielectric spectroscopy techniques. Scanning electron microscopy (SEM) is widely used in the characterization of amorphous solid dispersions. Effective characterization plays a critical role in the development of pharmaceutical amorphous solid dispersions.
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