Abstract
A structural study of the inclusion compound of tolbutamide with β-cyclodextrin (β-CD) in the solid state was attempted by means of carbon-13 high resolution solid-state nuclear magnetic resonance (NMR) experiments. The change in chemical shift of tolbutamide suggested that the phenyl moiety of the drug molecule was included in the cavity of β-CD in the solid state. This view was also supported by the change of the C-H out-of-plane vibration of the phenyl moiety of tolbutamide in the Raman spectrum. The solid-state NMR technique appears to be useful for studies on the nature of inclusion compounds of drug molecules with β-CD.
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