Abstract
β2-Microglobulin (β2m) is a 99-residue protein with a classical immunoglobulin fold that constitutes the light chain of the MHC-I complex. In long-term hemodialysis patients, the concentration of β2m in the blood serum is highly elevated and the protein forms amyloid fibrils that typically deposit in osteoarticular tissues. Although there have been numerous studies that have addressed the process of fibril formation and the structure of the fibrils formed by a small fragment of the protein, atomic level structural information on the full-length fibrils is still lacking.
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