Abstract
The use of two different allylic “handles” has been investigated in the solid-phase synthesis of protected peptides. Very high yields for the cleavage of peptides from the resin, under mild conditions which preserve side-chain protecting groups can be achieved by carrying out the cleavage reaction in 2:2:1 THF/DMSO/0.5 M HCl, using morpholine as nucleophile and Pd(Ph 3P) 4 as catalyst.
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