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Abstract
The synthesis and the use of new N-1-dinitrophenyl-inosine based solid support is reported. The support, which binds the nucleoside by a 5 ′-O-monomethoxytrityl function, reacting with N-nucleophiles allowed the synthesis of a small library of N-1 alkylated inosine and AICAR derivatives. Moreover, the obtained supports, after the cleavage of the 2 ′ -3 ′ ribose bond, furnished a set of new N-1 alkylated-2 ′ -3 ′ -secoinosine derivatives in high yields.
Published Version
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