Solid phase synthesis of cyclic peptides by oxidative cyclative cleavage of an aryl hydrazide linker—synthesis of stylostatin 1

Claudia Rosenbaum,Herbert Waldmann

doi:10.1016/s0040-4039(01)01075-9

Solid phase synthesis of cyclic peptides by oxidative cyclative cleavage of an aryl hydrazide linker—synthesis of stylostatin 1

Claudia Rosenbaum, Herbert Waldmann

https://doi.org/10.1016/s0040-4039(01)01075-9

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Journal: Tetrahedron Letters	Publication Date: Jul 24, 2001
Citations: 73

Affiliation: Max Planck Institute of Molecular Physiology

#Synthesis Of Cyclic Peptides #Cyclative Cleavage #Synthesis Of Peptides #Intramolecular Cleavage #Labile Linker #Oxidative Cleavage #Hydrazide Linker #Aryl Hydrazide #Solid Phase Synthesis #Cyclic Peptides

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The synthesis of cyclic peptides using an oxidation labile aryl hydrazide linker is reported. After oxidation with NBS release from the resin is triggered via an intramolecular cyclative cleavage which proceeds without racemization.

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Solid phase synthesis of cyclic peptides by oxidative cyclative cleavage of an aryl hydrazide linker—synthesis of stylostatin 1