Abstract
A general method for the solid phase synthesis of tetrahydro-β-carbolines is described. Resin bound tryptophan residues or non-peptide structures carrying 3-(2-aminoethyl)indole structures react rapidly under mild reaction conditions and in high yields with aldehydes to produce C-l substituted 1,2,3,4-tetrahydro-β-carbolines in a Pictet-Spengler reaction. The method can be employed to readily produce a wide range of tetrahydro-β-carbolines in combinatorial chemistry.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
