Abstract
Solid-phase microextraction (SPME) was investigated as sample preparation for the assay of the neuroleptic drug clozapine in human plasma. A mixture of human plasma, water, loxapine as internal standard and aqueous NaOH was extracted with a 100 μm-polydimethylsiloxane-(PDMS)-fiber for 30 min. The analyte and internal standard were well separated in the gas chromatogram. The calibration was linear and passed the origin. Accuracy and precision as well as the influence of changes of the matrix were investigated. No interfering drug was found. It is concluded that the method can be used in the therapeutic drug monitoring of clozapine.
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