Abstract
We report DGA extraction chromatography isolation of 51Mn from isotopically enriched 54Fe. The method has been studied in semi-automated and automated realizations. The former achieves a decay corrected radiochemical yield of 78±1% (n=3) and a separation factor of (1.0±0.8) x 105 (n=3). With GE HealthCare's Solid Target Platform (STP) and FASTlab the latter, fully automated method achieves a decay corrected radiochemical yield of 87±1% (n=3) and a separation factor of (2.7±0.9) x 104 (n=3). Both setups efficiently isolate cyclotron-produced 51MnCl2 suitable for human administration as determined by developed Chemistry, Manufacturing, and Controls (CMC) acceptance criteria, and support exploration of 51Mn as a clinical diagnostic tool.
Published Version
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