Solid particulates of drug-β-cyclodextrin inclusion complexes directly prepared by a spray-drying technique

Abstract

Inclusion complexes of drugs (acetaminophen, indomethacin, piroxicam and warfarin) with β-cyclodextrin were experimentally prepared by using a spray-drying technique. The spray-dried products were evaluated by X-ray diffractometry, differential scanning calorimetry and IR spectroscopy. The micromeritic properties and dissolution behaviour of spray-dried products were examined. It was found that the spray-drying technique could be used to prepare the amorphous state of drug inclusion complexes. The flowability and compressibility of the spray-dried products were poor, due to the small particle size formed by the spray drying process. However, the dissolution rates of drugs from tablets made by the spray-dried products were faster than those of the pure drug and the physical mixture of drug and β-cyclodextrin. The enhanced dissolution rate of spray-dried products might be attributed to the decreased particle size, the high-energetic amorphous state and inclusion complex formation.