Dissolution Characteristics of Nifedipine Complexes with β-Cyclodextrins

Abstract

Formation of nifedipine complexes with P-cyclodextrin, hydroxypropyt-& cyclodextrin, and DIMEB in solution was studied by the phase solubility method. Solid complexes of nijedipine were prepared by partial and complete solubilization of nifedipine using the freeze- and spray-drying techniques. The complexation led to an improvement in the dissolution rate of the drug. The relative potency of P-cyclodextrins to enhance the dissolution rate of nifedipine was in order: pcyclodextrin < hydroxypropyl-P-cyclodextrin < DIMEB, which clearly fits the magnitude of stability constant data of the complexes. The dissolution rates of the free drug, complexes, and physical mixture of drug and cyclodextrins from constant su@ace area disks were also investigated.