Abstract
ABSTRACTSolid Papillary Carcinoma (SPC) of the breast is a rare tumor with an incidence of less than 1%, mainly affecting elderly females. It is morphologically characterized by well-defined nodules with low-grade nuclear features associated with fibrovascular cores and shows neuroendocrine differentiation. SPC can be in-situ or invasive but has a favorable prognosis. It is a morphological mimicker of some pre-malignant conditions leading to its frequent misdiagnosis. An appropriate immunohistochemical (IHC) panel workup helps in distinguishing this tumor from its various morphological mimics. In this report, we present one such case of SPC with a small focus of invasion, reviewing the literature.
Highlights
Solid papillary carcinoma (SPC) is an uncommon malignancy of elderly females
It is said to originate from expanded ducts and mostly involves the central region of the breast. It is composed of well-circumscribed nodules with fibrovascular cores along with the presence of low-grade ductal cells. Their microscopic appearance may often be misinterpreted for other lesions such as florid ductal hyperplasia, lobular neoplasia, intracystic papillary carcinoma, and low nuclear grade ductal carcinoma in situ (DCIS).[2]
Elderly females and microscopically characterized by solid cellular proliferation of neoplastic cells supported by fibrovascular cores and forming circumscribed nodules.[7]
Summary
Solid papillary carcinoma (SPC) is an uncommon malignancy of elderly females. It has an incidence of less than 1%, with the mean age of presentation being 70 years.[1]. It is said to originate from expanded ducts and mostly involves the central region of the breast It is composed of well-circumscribed nodules with fibrovascular cores along with the presence of low-grade ductal cells. Their microscopic appearance may often be misinterpreted for other lesions such as florid ductal hyperplasia, lobular neoplasia, intracystic papillary carcinoma, and low nuclear grade ductal carcinoma in situ (DCIS).[2]. The hematoxylineosin (H&E) stained sections revealed a tumor arranged in circumscribed large cellular nodules, closely apposed and expanded, separated by bands of the fibrovascular stroma. These nodules had foci of tumor arranged in papillae with fibrovascular cores. Given the favorable histology and pT2N0 stage, she is currently on adjuvant endocrine therapy
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