Clinicopathologic analysis of 12 patients with solid papillary carcinoma of the breast

Abstract

Objective To analyze the clinicopathologic features, diagnosis and different diagnosis of solid papillary carcinoma (SPC) of the breast. Methods The clinical data and pathological section, including HE and immunohistochemical staining slice, of 12 cases of SPC in People's Hospital of Shanxi Province from December 2008 to August 2014 were analyzed. Simultaneously, a literature search was conducted by utilizing Pub Med for all reported cases in English from November 1995 to October 2014. Results All cases were female, aged from 50 to 77 years old, manifested as mass or nipple discharge. Histologically, all cases appeared as multiple, well-circumscribed nodules filled by monotonous, low-moderate grade cell separated by fibrovascular cores. Immunohistochemically, CgA, Syn, ER and PR were positive in 12, 11, 9 and 5 cases, respectively. Her-2 presented as 1+ in 1 case (1/12) with invasive mucinous carcinoma, and locally poor positive in 2 cases without invasive component, while CK5/6 was negative in all cases. p63 and CK5/6 were positive in 6 and 5 cases at the location of axis of papillary, respectively. Meanwhile, 8 and 7 cases at the border of duct, respectively. Conclusion SPC is an uncommon breast tumor, which presents with specific clinicopathologic features. Key words: Solid papillary carcinoma; Clinical pathology; Diagnosis