Abstract
Solid lipid nanoparticle (SLN) is a unique colloidal system used to deliver drugs which is nontoxic, biodegradable, showing good biocompatibility, and have small particle size. The possibility of SLN to deliver the brain drugs without damaging the brain-blood barrier (BBB) makes SLN an advanced central nervous system (CNS) drug delivery system. SLNs delivering drugs to CNS are mostly prepared by applying high energy homogenization method to achieve a better surface modification. The central topic of this article is how the SLN can overcome the BBB and help treat the central neural system disease. Also, SLNs contain levodopa can go through the BBB to help treat Parkinson’s and SLNs coated with chitosan and loaded with ferric acid to treat Alzheimer’s Disease (AD) are highlighted in this article. The effectiveness of SLNs compared with traditional therapy is shown in the article. Additionally, further studies are needed to focus on higher encapsulation efficiency and drug load efficiency as well as the targeted intranasal drug delivery.
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