Abstract
Aim: This study aimed to enhance the dissolution profile of indomethacin by formulating oro-dispersible tablets, using the Solid Dispersion technique and PEG 6000 and PVP K-30 as carriers. Method: Solid Dispersion (SD) of indomethacin were prepared using the kneading method. Pre-compression studies include evaluating granules' density and flow properties, while post-compression studies assessed tablet properties such as hardness, friability, wetting time, dissolution, drug content and material interactions. Result: All pre- and post-compressional parameters were found within pre-determined limits. FTIR indicated no remarkable interaction between the polymers and the drug in the SDs. The dissolution study showed that the formulation with a 1:1 ratio of indomethacin to PVP K-30 and PEG 6000 exhibited the fastest dissolution rate, releasing 99.53% of the drug within 15 minutes. Conclusion: The study successfully formulated oro-dispersible tablets of indomethacin using the SD technique with PVP K-30 and PEG 6000 as carriers. These SD granules exhibited excellent flow properties. Whereas tablets showed appropriate physical characteristics, and rapid dissolution rates, which can improve effectiveness of the drugs like indomethacin. This approach offers a promising solution for patients who have trouble taking tablets.
Published Version
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