Abstract
The 5 mol.% zirconium-incorporated 58S bioactive glass (Zr-BG) was modified by addition of magnesium (Mg). These BGs were synthesizedby substitution of CaO with MgO (0, 1, 3, 5 and 7 mol.%) through the sol-gel method. The SEM, FTIR and XRD were confirmed the formation of hydroxyapatite (HA) on BGs surfaces, after 7th day of immersion in simulated body fluid (SBF) solution. The results of MTT assay and alkaline phosphatase (ALP) activity analyses showed that the specimen with 5 Zr and 5 Mg (mol.%) in composition stimulated the cell proliferation and ALP activity more than the other specimens. Mechanical properties was proved by Vickers hardness test. The ZBG-M3 and ZBG-M5 were introduced as the reliable BGs due to the best synergetic effect of both ions through in vitro evaluations and candidates for further in vivo experiments.
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