Soft mechanics and fracture properties of cartilage and cartilage-inspired soft network materials

Abstract

Articular cartilage (AC) is a soft tissue that provides a smooth cushion and distributes the mechanical load in joints. As a material, AC is remarkable. It is only a few millimeters thick, can bear up to ten times our body weight over 100-200 million loading cycles despite minimal regenerative capacity, and still avoids fracturing. Such properties are desperately needed for tissue engineering, tissue repair, and even soft robotics applications. I will discuss the structural origins of and microscopic mechanisms leading to AC's exceptional mechanical properties using the framework of rigidity percolation theory and compare our predictions with experiments. Our results provide an understanding of the tissue depth-dependent mechanical properties and how tissue mechanics changes in response to changes in tissue composition during diseases such as osteoarthritis. By combining this framework with biopolymer double networks, we show how micro-structure, composition, and constitutive mechanical properties can be tuned to resist and blunt cracks in cartilage-like soft materials. The flexibility in resulting material properties and ease of implementation can be harnessed to fabricate artificial tissue constructs with tunable mechanics. I will conclude with a discussion of new results from structurally inhomogeneous soft network materials that provide insights towards achieving this future.