Abstract
Sodium-dependent high affinity choline transport has a number of properties suggesting an important role in a functioning cholinergic neuron. One of these properties, namely its coupling to neuronal activity, suggests that it is at least one of the rate-limiting and regulatory steps in the formation of acetylcholine. In vitro studies show that depolarization and calcium influx cause the uptake activation in vivo. Since sodium-dependent uptake “follows” neuronal activity, it could be used as a simple measure of relative change in the activity of cholinergic neurons. Using this approach, evidence was obtained indicating that nigro-striatal dopaminergic neurons modulate the activity of striatal cholinergic neurons.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
