Abstract
Sodium-dependent high affinity choline transport has a number of properties suggesting an important role in a functioning cholinergic neuron. One of these properties, namely its coupling to neuronal activity, suggests that it is at least one of the rate-limiting and regulatory steps in the formation of acetylcholine. In vitro studies show that depolarization and calcium influx cause the uptake activation in vivo. Since sodium-dependent uptake “follows” neuronal activity, it could be used as a simple measure of relative change in the activity of cholinergic neurons. Using this approach, evidence was obtained indicating that nigro-striatal dopaminergic neurons modulate the activity of striatal cholinergic neurons.
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