Abstract
A short review of experimental findings is presented relevant to the hypothesis that manic-depressive disorders are linked to disturbances of internal synchronization of bodily functions in the circadian frequency range. So far, there is no conclusive evidence that such disturbances play a considerable role in depression, since true desynchronization is suggested by no more than two long-term, single-case studies. However, divergent and/or more variable phase relations of various functions could be demonstrated in several cross-sectional studies. Mainly bipolar depressed patients seem to be affected.
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