Abstract
Sodium Valproate and Levetiracetam Treatment in Children: Their Effects on Serum Paraoxonase/ Arylesterase Activities
Highlights
Epilepsy is the most commonly seen chronic neurological disorder of the childhood, whose underlying pathophysiological mechanisms have not been well-understood yet, which is categorized in a broad spectrum as structural, metabolic, genetic, immune, infectious and of unknown etiology and affects 0.5-1% of the children [1,2]
Investigation of effects of seizures and used antiepileptic drugs on serum Paraoxonase 1 (PON1) and PONAryl activities in patients diagnosed with epilepsy and simple febrile convulsion was aimed
This case control study was conducted with patients underage of 18 years who admitted to Pediatric Emergency Department of Necmettin Erbakan University Meram Faculty of Medicine with complaint of seizure between the dates January 2018 and April 2018. 30 patients using sodium Valproate and 30 patients using levetiracetam, who were being followed-up due to diagnosis of epilepsy, and 30 patients diagnosed with simple febrile convulsion were included in the study; the study was concluded after reaching to the target number of patients
Summary
Epilepsy is the most commonly seen chronic neurological disorder of the childhood, whose underlying pathophysiological mechanisms have not been well-understood yet, which is categorized in a broad spectrum as structural, metabolic, genetic, immune, infectious and of unknown etiology and affects 0.5-1% of the children [1,2]. In the literature, there is a great number of studies regarding effect of antiepileptic drugs on oxidant or antioxidant enzymes [7]. Simple febrile seizures are generally benign but use of high amounts of glutamate and high oxygen consumption due to increased metabolic activity of the brain during seizure lead to oxidative stress [8]. Due to the thought that Paraoxonase 1 (PON1) and arylesterase (PONAryl) have the ability to hydrolyze organophosphate compounds and aromatic carboxylic esters, and protects high-density lipoprotein (HDL) and lowdensity lipoprotein (LDL) from lipid peroxidation, its antioxidant effects have been highlighted. Investigation of effects of seizures and used antiepileptic drugs on serum PON1 and PONAryl activities in patients diagnosed with epilepsy and simple febrile convulsion was aimed
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