Abstract
Antibiotics are frequently employed in the therapy of staphylococcal pyodermas, yet evidence that the lesions are benefited has never been confirmed by controlled studies. Comparison of oral sodium oxacillin and placebo therapy for staphylococcal pyoderma was made in 41 patients, by means of a random doubleblind technique. Routine therapy, including moist heat, incision, and drainage, was employed in every case. In an evaluation period of seven days, all patients receiving sodium oxacillin were significantly improved; about two thirds of the patients showed a satisfactory response while on placebo therapy. Fewer new lesions developed during the regimen of sodium oxacillin. The high incidence (33%) of penicillin-resistant staphylococcal infections encountered in this out-patient study points up the value of penicillinase-resistant penicillin when antibiotics are used.
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