Abstract
Sixty symptomatic patients, with recurrent cardiac arrhythmias resistant to conventional antiarrhythmic therapy, were treated with orally administered sodium diphenylhydantoin to assess the antiarrhythmic efficacy of the drug. The arrhythmias seen were (1) premature ventricular contractions, (2) paroxysmal atrial tachycardia, (3) paroxysmal atrial fibrillation, (4) premature atrial systoles, (5) premature nodal systoles, and (6) chronic atrial flutter. On an initial regimen of 100 mg three times daily, 37 of the 60 patients had an excellent response in that they have maintained regular sinus rhythm over an average of 16.8 months to date. A moderate response was obtained in six additional patients in whom there was a marked reduction in the frequency of the arrhythmia and the severity of symptoms. Six other patients failed to respond to the medication, and 11 were forced to discontinue taking the drug because of the development of side effects. No blood dyscrasias were seen.
Published Version
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