Abstract
The effect of 72 h fasting on the transmural electrical potential difference (P.D.), the unidirectional fluxes, and the net flux of sodium and the net transport of fluid across the jejunum of rats was investigated. Everted jejunal segments were incubated in 12 ml of Krebs–Ringer bicarbonate solution containing 5.55 mM glucose on either side for 1 h at 37 °C. Seventy-two hours fasting caused a 63% increase in the transmural P.D., a 60% increase in the flux of Na from the mucosal to the serosal side, and a 48% increase in the flux of Na from the serosal to the mucosal side. The net mucosal to serosal Na flux increased by 97%. There was also a 41% increase in fluid transport across the intestine of fasted rats. The concomitant increase in sodium and fluid transport and in transmural P.D. is consistent with the current hypotheses of fluid and sodium transport.
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