Sodium ampicillin release from biocompatible hydrogel with enhanced antibacterial characteristics

Abstract

The goal of this research is to develop an intelligent carrier that can control the release of medications in response to particular triggers. A novel carrier was created by combining different amounts of chitosan and polyvinylalcohal along with specific amount of cinnamon extract to enhance the antibacterial response of the prepared hydrogels. A non-hazardous crosslinker 3-Aminopropyl(diethoxy)methylsilane (3-APDEMS) was used to study its effect on the physical and chemical properties of the produced injectable hydrogels as well as the controlled drug release behaviour. The hydrogels swelling behaviour was assessed in a range of solvent environments and the results indicated that the swelling ratio decreased as the concentration of 3-APDEMS rose. The hydrogels showed the most swelling at acidic pH values and the least swelling at basic and neutral pH values. They are appropriate for use in injectable controlled medication delivery systems due to their unique pH-sensitive characteristic at pH 7.To evaluate its release profile in this particular setting, ampicillin sodium salt was effectively added to the best hydrogel formulation (which contained 100 μL cinnamon extract and 150 μL 3-APDEMS).The results showed that the release of ampicillin sodium (AMS) was regulated in PBS (7.4), reached up to 98.236 % release over 90 min.The utilisation of these hydrogels as a cutting-edge material for physiological pH-controlled injectable medication delivery and other biological applications is supported by these results.