Abstract
The objective of present study was to prepare composite microbeads of psyllium arabinoxylan and sodium alginate by ionotropic gelation method using calcium chloride as a cross linker and was further evaluated for release study. The effect of concentration of sodium alginate/arabinoxylan and concentration of calcium chloride on the entrapment efficiency and on % release were studied employing 2-factor, 3-level central composite experimental design. The results of the study revealed that interaction effect of the concentration of sodium alginate/arabinoxylan and calcium chloride influenced the entrapment efficiency and release of diclofenac sodium significantly. The optimal calculated parameters were found to be concentration of sodium alginate/arabinoxylan-5 and concentration of calcium chloride-0.75 M, that provided microbeads with entrapment efficiency-64.4 % and release of 28.5 % of the drug over 8 h period of study. Further, arabinoxylan–sodium alginate mucoadhesive microbeads were found to sustain the release of diclofenac sodium over a period of 8 h following zero order kinetics with the mechanism of release being diffusion.
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