Sociodemographic and Clinical-pathological Study of Molecular Subtitles of Breast Carcinoma in a Reference Unit of Maranhão.

Ana Paula Almeida Miranda Reis,Camila Rosa De Albuquerque,Cecilma Miranda De Sousa Teixeira,Adriano Rêgo Lima De Medeiros,Karlla Zolinda Cantão Chaves,Mateus Rufino Melo

doi:10.1055/s-0040-1719147

Ana Paula Almeida Miranda Reis, Camila Rosa De Albuquerque + Show 4 more

Open Access

https://doi.org/10.1055/s-0040-1719147

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Abstract

To evaluate the distribution of the main sociodemographic and clinical-pathological characteristics in women with breast cancer according to the molecular profile by immunohistochemistry. A cross-sectional, retrospective, analytical and quantitative study was performed, with an analysis of 137 medical records from January 2015 to December 2018 of women attending the High Complexity in Oncology Unit of the city of Imperatriz, state of Maranhão, Brazil. The immunohistochemical profile of tumors based on the estrogen and progesterone receptor, Human Epidermal growth factor Receptor-type 2 (HER2) overexpression and Ki67 cell proliferation index was defined, from which six molecular subtypes were determined: luminal A, luminal B-HER2 negative, luminal B-HER2 positive, triple negative, overexpression of HER2 and inconclusive. A total of 52.6% of the patients were postmenopausal, mean age 52.1 years old, brown (56.2%), had a schooling level < 9 years (40%), staging > IIB (52.6%) and 23.4% had metastasis. Invasive ductal carcinoma accounted for 84.7%, tumor size was 2 to 5 cm (48.9%), with lymph node involvement (56.2%), axillary lymphadenectomy in 67.2%, and mastectomy in 73.7% of the patients. The most frequent molecular subtype was the luminal B-HER2 negative (36.5%), and the luminal A subtype showed characteristics of better prognosis when compared with the others. It was concluded that in the association of molecular subtypes with sociodemographic and clinical-pathological characteristics, there were no statistically significant results obtained, except for complementary therapy, referring to hormone therapy, and there was a high index of metastasis at diagnosis, which was a worrying factor and indicative of failures in the screening and early diagnosis of this population.

Highlights

Breast cancer or breast carcinoma is an important public health problem due to its high incidence and mortality, in addition to being the major cause of cancer death in women worldwide.[1]
It was concluded that in the association of molecular subtypes with sociodemographic and clinical-pathological characteristics, there were no statistically significant results obtained, except for complementary therapy, referring to hormone therapy, and there was a high index of metastasis at diagnosis, which was a worrying factor and indicative of failures in the screening and early diagnosis of this population
Foi definido o perfil imunohistoquímico dos tumores baseado na avaliação dos receptores de estrogênio e progesterona, superexpressão de Human Epidermal growth factor Receptor-type 2 (HER2) e índice de proliferação celular Ki67, de onde foram determinados seis subtipos moleculares: luminal A, luminal B-HER2 negativo, luminal B-HER2 positivo, triplo negativo, superexpressão de HER2 e inconclusivo

Summary

Introduction

Breast cancer or breast carcinoma is an important public health problem due to its high incidence and mortality, in addition to being the major cause of cancer death in women worldwide.[1]. Accumulated evidence suggests that this presentation can be justified by the complexity of this neoplasm and the arsenal of molecular changes that lead to different responses to treatment, and should receive different therapeutic strategies.[4,5]

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