Social determinants of health profiles and survival among US cancer survivors: A cluster analysis.

Abstract

402 Background: Healthcare payers and clinicians increasingly focus on social determinants of health (SDOH) to reduce disparities in care and improve patient outcomes in US. Prognostic value of single SDOH factors has been described, but not for clusters of multiple SDOHs. We characterize cancer survivors by their SDOH profiles and examine associations with survival. Methods: 11,237 cancer survivors were identified from the 2013-2018 National Health Interview Survey (NHIS) with linkage to NHIS Mortality Files. 9 SDOHs were included in 5 a priori identified domains: 1) healthcare access (medical financial hardship, delayed care due to transportation and/or other barriers); 2) economic instability (unemployment, food insecurity, housing insecurity); 3) social isolation (marital status); 4) education and literacy (< high school education); and 5) neighborhood quality (low neighborhood social cohesion (nSC) based on 4 item scale developed by the Project on Human Development in Chicago Neighborhoods Community Survey). The most significant SDOH in each domain was identified with Cox regressions. We then clustered patients into 5 groups using the inter-person Gower distance of the 5 selected SDOHs and examined survival among each cluster adjusting for age, sex, race, region, and survey era. Results: 5 distinct clusters of cancer survivors were identified with top-ranking SDOHs in each domain: 1) Healthy Hopefuls: young, employed, and married with fewer socio-economic and health burdens; 2) Independent Phoenixes: single, employed rising above adversity, maintaining health and financial wellness; 3) Enduring Companions: older, unemployed, and married navigating health challenges while maintaining financial stability; 4) Solo Warriors: older, single, unemployed with health complications and financial hardships; and 5) Resilient Overcomers: unemployed minorities in low-quality neighborhoods, overcoming the obstacles of higher health and socio-economic challenges. Groups 3, 4, and 5 had worse survival than group 1 in adjusted analyses (Table). Conclusions: SDOH profiles were strongly associated with survival in US cancer survivors. Findings support the need to identify SDOH profiles in efforts to personalize mitigation strategies and enhance long-term wellness.[Table: see text]