Abstract
Patients with resectable oesophageal cancer (OeC) have a 5-year overall survival of 25-47%. One of the strongest prognostic factors is lymph node (LN) status. The regional tumour draining LNs play an important role in the host anti-tumour immune response. It has been suggested that LN microarchitecture (number of germinal centres, sinus histiocytosis, expansion of the paracortex or medulla) changes in response to exposure to tumour antigens. However, it is currently not known whether there are specific morphological changes in regional LNs after neoadjuvant cytotoxic chemotherapy.
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