Abstract
The association of major histocompatibility complex class I chain-related gene A (MICA) single nucleotide polymorphism (SNP) rs2596542G>A and hepatocellular carcinoma (HCC) has been broadly studied, with inconsistent results. Therefore, we conducted the current meta-analysis to better elucidate the roles of SNP rs2596542G>A in HCC. Eligible articles were searched in PubMed, CNKI, Wanfang, Embase, VIP, Web of Science, and CBM databases up to November 2018. Odds ratios (ORs) and 95% CIs were applied. A total of 11 articles, including 4528 HCC patients and 16,625 control subjects, were analyzed. Results revealed that rs2596542G>A was significantly associated with HCC in the heterozygote (G/A versus A/A, P=0.006, OR = 0.854; 95% CI: 0.763–0.956); and dominant (G/G + G/A versus A/A; P=0.021; OR = 0.796; 95% CI: 0.655–0.967) genetic models. Nevertheless, we also detected significant associations between rs2596542G>A and HCV-induced HCC. Additionally, according to our analyses, SNP rs2596542G>A was not correlated with HBV-induced HCC. In conclusion, our findings suggest that MICA SNP rs2596542G>A is associated with HCC susceptibility amongst the Asian, Caucasian, and African ethnicity in certain genetic models. Specifically, MICA SNP rs2396542G>A is associated with risk of HCV-induced HCC, not HBV-induced HCC.
Highlights
Received: 13 August 2018Revised: April 2019Accepted: April 2019Accepted Manuscript Online: 09 April 2019Version of Record published: 07 May 2019Liver cancer is one of the leading causes of death worldwide responsible for nearly 746,000 deaths per year.It is reported to be the fifth most common cancer in men (7.5% of all cancers) and the ninth in women (3.4% of all cancers) occurred in 2012 [1]
The following inclusion criteria were applied: (1) conducted as a case-control study on the association of MICA single nucleotide polymorphism (SNP) and liver cancer risks; (2) odds ratio (OR) and 95% CI can be counted based on the genotype frequencies provide in the study; (3) the genotype distributions in control groups should conform to the Hardy–Weinberg equilibrium (HWE); and (4) the study must be administrated in human samples
Two articles were excluded for duplication, nine articles were excluded for no usable data, six articles were excluded for not SNP and liver cancer studies, and one article was exclude for not case-control study
Summary
Received: 13 August 2018Revised: April 2019Accepted: April 2019Accepted Manuscript Online: 09 April 2019Version of Record published: 07 May 2019Liver cancer is one of the leading causes of death worldwide responsible for nearly 746,000 deaths per year.It is reported to be the fifth most common cancer in men (7.5% of all cancers) and the ninth in women (3.4% of all cancers) occurred in 2012 [1]. Hepatocellular carcinoma (HCC), which is mainly associated with liver cirrhosis related to chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection, accounts for the majority pathological type of primary liver cancer [2,3]. CLD is a progressive liver disorder and consists of different liver pathologies, including hepatitis, fibrosis, cirrhosis, and eventually HCC [6,7]. Though both HBV and HCV can contribute to HCC, the role of them in HCC development is reported to be distinct [8]. One of the most extensively studied inherited genetic risk factors for virus-induced HCC are variants of the human major histocompatibility complex class I chain-related gene A (MICA) [11]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
