Abstract
Drug Development The glycosome is a peroxisome-like organelle that packages glycolytic enzymes of the parasites that cause sleeping sickness, Chagas disease, and leishmaniases. Dawidowski et al. designed small-molecule inhibitors to disrupt interactions between two of the proteins involved in peroxisome biogenesis (PEX5 and PEX14), which permit import of glycosomal matrix proteins from the cytoplasm. The small peptide–mimicking molecules kill the trypanosome parasites by causing metabolic collapse without interfering with human PEX homologs. Preliminary studies in mice confirmed an antiparasitic effect. Science , this issue p. [1416][1] [1]: /lookup/doi/10.1126/science.aal1807
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