Abstract
Alternative treatments are needed for steroid-resistant, Th17-mediated asthma. Signal transducer and activator of transcription 3 (Stat3) drives Th17 differentiation and is linked to Th17- and Th2-mediated airway inflammation. We hypothesized that C188-9, a small-molecule probe that inhibits Stat3 activation, can prevent HDM-induced airway inflammation by blocking production of Th17- and Th2-type cytokines.
Full Text
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call