Abstract
Small Intestinal Bacterial Overgrowth in Children with Functional Dyspepsia and Duodenal Ulcer Disease, Associated with Helicobacter Pylori Infection
Highlights
Helicobacter pylori (HP) infection is present in more than the half of the world population
This study demonstrated the high prevalence of Small intestinal bacterial overgrowth (SIBO) in patients with duodenal ulcer disease (DUD) and functional dyspepsia, associated with HP
Chronic gastroduodenal pathology was associated with HP infection in all patients, which was diagnosed for the first time
Summary
Helicobacter pylori (HP) infection is present in more than the half of the world population. Not all infected people exhibit diseases associated with this bacterium. Human intestinal microbiota creates complex polymicrobial ecology. This is characterized by its high population density, wide diversity and complexity of interaction. The duodenum and the proximal jejunum normally contain small numbers of bacteria [3,4]. Small intestinal bacterial overgrowth (SIBO) is a very heterogeneous syndrome characterized by an increased number and/ or abnormal type of bacteria in the small intestine. Most authors consider diagnosis of SIBO to be the finding of ≥105 bacteria [i.e. Colonyforming units] per ml of proximal jejunal aspiration. Symptoms of SIBO are directly associated with bacterial metabolism, intestinal mucosa damage that leads to impaired absorption of fat, proteins, carbohydrates, and fat-soluble vitamins [4,5,6]. The course of SIBO is considered to be completely asymptomatic [5]
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