Small doses of gentamicin drum indoor injection treatment of intractableMénière disease clinical observation of the impact of the hearing

Abstract

Objective:To study the effect of low-dose gentamicin intratympanic therapy on intractable Meniere's disease on hearing.Method:One hundred and forty cases of patients with ENT intractable Meniere's disease were selected in this clinical trial study,all patients were enrolled in the drum line intraventricular injection of low-dose gentamicin treatment.After two weeks' treatment in hospital,the patients followed-up for 1 years,all patients did pure tone audiometry,speech audiometry and on hearing threshold changes before and after treatment were comparatively analyzed; continu followed-up for 1 year and the patients' Meniere's disease therapeutic effect were analyzed.Result:After treatment,the follow up within a year of 120 patients(140 cases,20 cases were lost),36 cases never attack of vertigo symptoms,the total effective rate was 91.7%; all patients before treatment speech frequency was(67.2±2.1) dB after treatment(65.5±2.0) dB,the difference was not statistically significant(P>0.05); In the group of gentamicin treatment,all patients 1-3 kHz compare hearing thresholds and changes of 8 kHz before and after injection,the difference was not statistically significant(P>0.05); tinnitus,ear fullness episodes of a significant reduction in the overall incidence rate dropped to 2% from 7% after treatment,the difference was statistically significant(P<0.05) .Conclusion:For intractable Meniere's disease,a small dose of gentamicin intratympanic have a positive clinical effect,and no significant effect on hearing Thus,it is a worthy of promotion and application for low dose gentamincin intratympanic injection in intractable Meniere's disease.