Abstract
Studies on the relation between blood platelet adhesion and type and amount of polyether segments in copolyether-urethanes report a reduced platelet adhesion with increasing polyether content. We therefore assumed that combinations of polyethylene oxide (PEO) and polypropylene oxide (PPOX) might give materials with a good blood compatibility. Water-soluble PEO was attached to PPOX by UV initiated crosslinking. Films were tested on hydrophilicity, mechanical properties, protein adsorption and blood compatibility. The hydrophilicity was determined by swelling experiments. A compromise between hydrophilicity (PEO) and mechanical strength (PPOX) was met at a swelling of 0.5 (PPOX/PEO ratio : 90/10). In protein adsorption studies only small amounts of adsorbed proteins were found. Three blood material interaction in vitro tests, — kallikrein generation (factor XII activation), activated partial thromboplastin time and blood platelet adhesion —, gave good results: a low platelet adhesion and kallikrein generation and a high APTT value. Porous tubings (I.D. 1.3 mm) were fabricated by spinning from solution and implanted in the abdominal aorta of rats. Stress-strain diagrams were comparable to those reported for natural blood vessels.
Published Version
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