Abstract
The influence of ligation and colchicine treatment on the axonal transport of slowly migrating [ 3H]leucine-labelled proteins was studied in the vagus nerve of the rabbit. Two days after [ 3H]leucine labelling of the dorsal motor nucleus of the vagus nerve, ligation or local application of 60 m M colchicine immediately blocked the further progression of slowly migrating proteins distal to the site of treatment. Application of 50–100 μg colchicine to the nerve cell bodies 2 days after labelling blocked the transport of slowly migrating proteins within the next 24 h. It is suggested that contact between nerve cell body and the axon is necessary for the maintenance of the slow transport of proteins in these nerves.
Published Version
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