Abstract
This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Highlights
The circadian clock and sleep homeostasis are two key regulators that shape daily sleep behaviors in animals (Borbely, 1982)
These results suggest that sensory perception of dietary threonine is less likely responsible for sleep-promoting effects of dietary threonine (SPET)
We further found that flies fed nutrient-rich food containing additional protein sources exhibited SPET, higher concentrations of threonine were required (Figure 1—figure supplement 4)
Summary
The circadian clock and sleep homeostasis are two key regulators that shape daily sleep behaviors in animals (Borbely, 1982). Resistance to dieldrin (Rdl), a Drosophila homolog of the ionotropic GABA receptor, suppresses wakepromoting circadian pacemaker neurons in adult flies to exert sleep-promoting effects (Agosto et al, 2008; Chung et al, 2009; Liu et al, 2014a; Parisky et al, 2008). We have demonstrated that starvation induces the expression of metabolic enzymes for serine biosynthesis in Drosophila brains, and elevates free serine levels to suppress sleep via cholinergic signaling (Sonn et al, 2018). These observations prompted us to hypothesize that other amino acids may display neuro-modulatory effects on sleep behaviors
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
