Abstract
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Highlights
The circadian clock and sleep homeostasis are two key regulators that shape daily sleep behaviors in animals (Borbely, 1982)
These results suggest that sensory perception of dietary threonine is less likely responsible for sleep-promoting effects of dietary threonine (SPET)
We further found that flies fed nutrient-rich food containing additional protein sources exhibited SPET, higher concentrations of threonine were required (Figure 1—figure supplement 4)
Summary
The circadian clock and sleep homeostasis are two key regulators that shape daily sleep behaviors in animals (Borbely, 1982). Resistance to dieldrin (Rdl), a Drosophila homolog of the ionotropic GABA receptor, suppresses wakepromoting circadian pacemaker neurons in adult flies to exert sleep-promoting effects (Agosto et al, 2008; Chung et al, 2009; Liu et al, 2014a; Parisky et al, 2008). We have demonstrated that starvation induces the expression of metabolic enzymes for serine biosynthesis in Drosophila brains, and elevates free serine levels to suppress sleep via cholinergic signaling (Sonn et al, 2018). These observations prompted us to hypothesize that other amino acids may display neuro-modulatory effects on sleep behaviors
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