Abstract
A 76-year-old male patient with Parkinson disease received long-term treatments with levodopa and benserazide hydrochloride tablets, carbidopa and levodopa controlled release tablets, and amantadine hydrochloride tablets. Due to the aggravation of the symptoms, oral piribedil sustained-release tablets 50 mg twice daily was added, whose dose was increased to thrice daily 1 month later. On day 3 of dose increase, the patient′s family member found that the patient developed unresponsiveness to verbal stimuli and the doctor found that the patient was in a state of sudden deep sleep. During the deep sleep attacks, his vital signs were normal and about 40 minutes later, the patient was awake. No abnormalities were found in cranial magnetic resonance imaging and electroencephalogram that same day. On day 10, the patient developed 2 times of deep sleep again, each time lasted for 30-40 minutes, and then relieved by himself. No abnormality was found in EEG. Sleep attacks caused by piribedil was considered. The dose of piribedil sustained-release tablets was gradually reduced and finally withdrawn. Sleep attacks did not recur. Key words: Piribedil; Parkinson disease; Sleep wake disorders; Narcolepsy
Published Version
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