Abstract
SKN-1/Nrf, A New Unfolded Protein Response Factor?
Highlights
Cell function requires simultaneous regulation of numerous processes, often under variable conditions
endoplasmic reticulum (ER) homeostasis requires coordination of protein translation, folding, and covalent modification; availability of energy and substrates; and maintenance of a redox environment that is suitable for disulfide bond formation
The unfolded protein response (UPR) is a eukaryotic signaling program that responds to ER stress by inhibiting protein translation, inducing protein folding chaperones, and directing the degradation of misfolded proteins [2,3,4] (Figure 1)
Summary
Cell function requires simultaneous regulation of numerous processes, often under variable conditions. Redox homeostasis in animal cells is controlled in part by a family of transcription factors represented by SKN-1 in C. elegans and Nrf1, Nrf2, and Nrf3 in mammals (Figure 1). SKN-1 and Nrf2 have well-established roles in promoting redox homeostasis and small molecule detoxification, and SKN-1 has been shown to promote longevity [5,6,7,8].
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