Abstract
In studies upon the antibody response in human subjects following administration of serum, Tuft and Ramsdell1, 2 have noted that normal serum is weakly antigenic and immune serum highly antigenic, as indicated in tests made for precipitins, skin sensitivity, anaphylactic antibodies and transferable human and guinea pig skin sensitizing antibodies. Administration of normal horse serum was followed by serum sickness however, identical in its clinical characteristics and about as frequently as was produced by the injection of immune serum.Since it is possible to produce in the rabbit, upon injection of a single large dose of normal or immune serum, a condition closely resembling or identical with serum sickness in man,3 an attempt was made to compare the antigenicity (as measured by precipitin response and appearance of skin sensitivity) of normal horse serum with that of immune serum, as produced by a single subscapular injection in this species. Three animals were injected with pooled normal horse serum, 5...
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