Abstract
ABSTRACT Amelanotic melanoma is a rare subtype of cutaneous melanoma. Sun exposure is a known primary risk factor; however, the mechanism for amelanosis is poorly understood. Amelanotic melanoma is challenging to recognize clinically because of absence of pigment and its resemblance to a variety of benign and malignant neoplasms. Detection often occurs at late or metastatic stages, leading to poorer outcomes. Surgical excision is the current standard of care, with adjuvant therapies under investigation. This article discusses the clinical assessment and management of AM to improve early recognition and patient outcomes.
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