Skeletal Editing-Nitrogen Deletion of Secondary Amines by Anomeric Amide Reagents.

Abstract

Late‐stage modification is highly desirable for the diversification and modification of biologically active compounds. Peripheral editing (e.g., C−H activation) has been the predominant methodology, whereas skeletal editing is in its infancy. The single‐atom N‐deletion using anomeric amide reagents constitutes a powerful tool to modify the underlying molecular skeletons of secondary amines. N‐pivaloyloxy‐N‐alkoxyamide is easily prepared on a large scale and promotes C−C bond formation in good yields under the extrusion of N2 for a variety of (cyclic) aliphatic amines. The exploitation of widely available amines allows the use of existing amine synthesis protocols to translate into the construction of new C−C bonds, enabling ring contraction and the potential for structure optimization of biologically active compounds.