Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma.

Nobuko Enomoto,Asuka Takeyama,Goji Tomita,Kyoko Ishida,Fumihiko Yagi,Ayako Anraku

doi:10.1155/2015/186249

Nobuko Enomoto, Asuka Takeyama + Show 4 more

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https://doi.org/10.1155/2015/186249

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Purpose. To evaluate the relationships among the optic nerve head (ONH) area, macular ganglion cell complex (mGCC) thickness, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, and visual field defects in patients with primary open angle glaucoma (POAG). Methods. This retrospective study included 90 eyes of 90 patients with POAG. The ONH area, rim area, mGCC thickness, and cpRNFL thickness were measured using optical coherence tomography. Mean deviation (MD) was measured using standard automated perimetry. The relationships among clinical factors including age, refraction, the ONH area, the rim area, the mGCC thickness, the cpRNFL thickness, and MD were evaluated using correlation coefficients and multiple regression analyses. Results. The significant correlation of the ONH area with refraction (r = 0.362, P < 0.001), the mGCC thickness (r = 0.225, P = 0.033), and the cpRNFL thickness (r = 0.253, P = 0.016) was found. Multiple regression analysis showed that the ONH area, rim area, and MD were selected as significant contributing factors to explain the mGCC thickness and cpRNFL thickness. No factor was selected to explain MD. Conclusions. The ONH area, in other words, the disc size itself may affect the mGCC thickness and cpRNFL thickness in POAG patients.

Highlights

Glaucomatous optic neuropathy is characterized by the progressive loss of retinal ganglion cells and their respective axons, which comprise the retinal nerve fiber layer (RNFL) [1]
The implication was that the number of nerve fibers in circumpapillary RNFL (cpRNFL) depends on the disc area and that it might be possible to decrease the variations in the measured cpRNFL thickness if the scan diameter was adjusted according to the disc diameter, this possibility was not supported by Huang et al [33] in normal healthy subjects
The optic nerve head (ONH) area was significantly correlated with refraction, the macular ganglion cell complex (mGCC) thickness, and the cpRNFL thickness

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Introduction

Glaucomatous optic neuropathy is characterized by the progressive loss of retinal ganglion cells and their respective axons, which comprise the retinal nerve fiber layer (RNFL) [1]. The ONH size is reportedly a possible risk factor for glaucomatous optic nerve damage [20,21,22,23,24]. The relationship between ONH size and glaucomatous optic nerve damage remains controversial. Several studies have found that the cpRNFL thickness measured at a fixed diameter is positively correlated with the optic disc area [31, 32]. The implication was that the number of nerve fibers in cpRNFL depends on the disc area and that it might be possible to decrease the variations in the measured cpRNFL thickness if the scan diameter was adjusted according to the disc diameter, this possibility was not supported by Huang et al [33] in normal healthy subjects. To the best of our knowledge, there are no published clinical reports evaluating

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