Abstract
Situs Inversus Totalis is a rare congenital condition with an autosomal recessive inheritance. Most of the people with SIT are asymptomatic, making its diagnosis a challenge. Although many cases of cancers coexisting with SIT have been reported in medical literature, the co-existence of RCC with SIT is extremely rare. We are presenting the 5th reported case in the published medical literature. Case Report: We report a case of a 65-year-old male who was presented with intractable back pain, difficulty in performing daily activities and unintentional weight loss. Evaluation of these symptoms revealed SIT, a right renal mass and widespread metastatic deposits. Immunohistochemical analysis confirmed the diagnosis of clear cell type of renal cell carcinoma. Conclusion: Situs Inversus is a rare congenital abnormality which may be associated with renal anomalies, Kartagener syndrome, and several types of malignancies. Further study is needed to characterize the genetic basis of SI and establish whether there is a causal basis between SI and the development of malignancy or not.
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